29 March, 2018
Neil Theise, professor of pathology at NYU Langone Health in NY, co-author on the study, said, "Initially, we were just thinking it's an interesting tissue, but when you actually delve into how people define organs, it sort of runs around one or two ideas: that it has a unitary structure or that it's a tissue with a unitary structure, or it's a tissue with a unitary function".
This series of spaces, supported by a meshwork of strong (collagen) and flexible (elastin) connective tissue proteins, may act like shock absorbers that keep tissues from tearing as organs, muscles, and vessels squeeze, pump, and pulse as part of daily function.
A study claims to have discovered a new human organ that could help scientists better understand its impact on diseases such as cancer. "The presence of fluid has important implications for tissue function and pathology", the team adds.
"What we saw in this layer of the bile duct is this open fluid filled space supported by this collagen bundle latticework", Theise, who now works at New York University School of Medicine told Reuters on Tuesday. It could be the interstitium that has to be breached by the cancer cells in order for them to spread he said.
In 2015 two of the study authors, Dr David Carr-Locke and Dr Petros Benias, from Mount Sinai-Beth Israel Medical Center, based in NY, were using a relatively new form of technology.
"Initially, we were just thinking it's an interesting tissue, but when you actually delve into how people define organs, it sort of runs around one or two ideas: that it has a unitary structure or that it's a tissue with a unitary structure, or it's a tissue with a unitary function", said Dr. Neil Theise, professor of pathology at NYU Langone Health in NY, who was a co-senior author of the study. Researchers also believe that the interstitium drains into the lymphatic system and acts as a source of lymph, a fluid that moves through the lymphatic system and removes bacteria from tissues.
EU, British negotiators hail major progress on Brexit deal
The EU secured agreement that Britain would offer residence rights to EU citizens who arrive after Brexit but before 2021. He argued that Mrs May had been able to "fudge" the issue until now but that strategy "doesn't work any more".
Theise says that this is found in interstitium, which totals about "10 litres of fluid" inside the human body.
The organ's structure and functionality may help researchers learn why certain types of cancer - such as skin, breast and stomach cancers - spread and lead to improved treatments against aggressive cancers. The researchers collect tissues using a technology called confocal laser. David Carr-Locke and Petros Benias made the discovery while investigating a patients bile duct for cancer. Newer approaches enable doctors to use this procedure to get a microscopic look at the tissue inside a person's gut at the same time, with some surprising results. Any thin spaces remaining in biopsy slides appear like tears in tissue, rather than the remains of previously fluid-filled compartments.
In the new study, the researchers first used pCLE on cancer patients who were undergoing surgery to remove the pancreas and the bile duct.
This supposed organ was unseen due to previous endoscopy equipment tampering with the structure of the networks, causing the organ to "appear like a hard wall of dense protective tissue, instead of a fluid-filled cushion". The imaging technique indeed showed the fluid-filled spaces in the connective tissue.
On a fundamental level, it says, "our findings necessitate reconsideration of numerous normal functional activities of different organs and of disordered fluid dynamics in the setting of disease, including fibrosis and metastasis" - that is, the spread of cancer.
Scientists are already studying whether analyzing the fluid in the new organ can allow for more early diagnosis of cancer.